Tpsb2 ELISA Kit for Mouse(Mus musculus) | EIAab.comTpsb2 ELISA Kit for Mouse(Mus musculus)

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Tpsb2 (Gene name),

Tryptase beta-2 (Protein name ), TRYB2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Tpsb2(Mcpt6);

Protein name:

Tryptase beta-2(Tryptase-2);

Alternative:

Mast cell protease 6(mMCP-6);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6.

Function:

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection.

Subcellular Location:

Secreted Released from the secretory granules upon mast cell activation.

Protein Attributes:

Sequence length:

276

Sequence:

50:

100:

150:

200:

250:

276:

QPNKPGIYTR | VTYYLDWIHR | YVPEHS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P21845

UniGene:

Mm.7409

Pfam:

PF00089

SMR:

P21845

Uniprot:

P21845

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ELISA Kit for Mouse Tryptase-2

Cat.:

E0258h

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96T

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ELISA Kit for Mouse Tryptase-2

Cat.:

E0258m

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96T

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ELISA Kit for Mouse Tryptase-2

Cat.:

E0258r

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96T

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CLIA Kit for Mouse Tryptase-2

Cat.:

U0258m

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96T

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CLIA Kit for Mouse Tryptase-2

Cat.:

U0258h

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96T

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CLIA Kit for Mouse Tryptase-2

Cat.:

U0258r

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Packing:

96T

Polyclonal Antibody for Mouse Tryptase-2

Cat.:

P0258Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Tryptase-2

Cat.:

P0258Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Tryptase-2

Cat.:

P0258Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Tryptase-2

Protein for Mouse Tryptase-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Cloning of the cDNA and gene of mouse mast cell protease-6. Transcription by progenitor mast cells and mast cells of the connective tissue subclass."
Reynolds D.S. , Gurley D.S. , Austen K.F. , Serafin W.E.
J. Biol. Chem.266:3847-3853(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Expression of a mast cell tryptase in the human monocytic cell lines U-937 and Mono Mac 6."
Huang R. , Abrink M. , Gobl A.E. , Nilsson G. , Aveskogh M. , Larsson L.G. , Nilsson K. , Hellman L.
Scand. J. Immunol.38:359-367(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Leaden X A1.
3.

"Genes for mast-cell serine protease and their molecular evolution."
Huang R. , Hellman L.T.
Immunogenetics40:397-414(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
strain: Leaden X A1.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
strain: FVB/N.
tissue: Colon.
5.

"Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases."
Reynolds D.S. , Stevens R.L. , Lane W.S. , Carr M.H. , Austen K.F. , Serafin W.E.
Proc. Natl. Acad. Sci. U.S.A.87:3230-3234(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 32-54
6.

"The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections."
Thakurdas S.M. , Melicoff E. , Sansores-Garcia L. , Moreira D.C. , Petrova Y. , Stevens R.L. , Adachi R.
J. Biol. Chem.282:20809-20815(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
7.

"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-98;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Mast cell.
8.

"The expression pattern of three mast cell specific proteases during mouse development."
Abraham D. , Oster H. , Huber M. , Leitges M.
Mol. Immunol.44:732-740(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE

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